[Selected Publications]
[Selected Publications]
Embedded Files
He, L*., Cho, S.*, and Blenis, J. (2025). mTORC1, the maestro of cell metabolism and growth. Genes Dev 39, 109–131. https://doi.org/10.1101/gad.352084.124
Cho, S., Chun, Y., He, L., Ramirez, C.B., Ganesh, K.S., Jeong, K., Song, J., Cheong, J.G., Li, Z., Choi, J., et al. (2023). FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1. Mol Cell 83, 3010-3026.e8. https://doi.org/10.1016/j.molcel.2023.07.017.
Cho, S.*, Lee, G.*, Pickering, B.F.*, Jang, C., Park, J.H., He, L., Mathur, L., Kim, S.-S., Jung, S., Tang, H.-W., et al. (2021). mTORC1 promotes cell growth via m6A-dependent mRNA degradation. Molecular Cell 81, 2064-2075.e8. https://doi.org/10.1016/j.molcel.2021.03.010.
Lee, G., Zheng, Y.*, Cho, S.*, Jang, C., England, C., Dempsey, J.M., Yu, Y., Liu, X., He, L., Cavaliere, P.M., et al. (2017). Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling. Cell 171, 1545-1558.e18. https://doi.org/10.1016/j.cell.2017.10.037.
[All publications]
[All publications]
1. Cho SY, Endress J, He L#, and Blenis J#. (2026). Understand 5-fluorouracil resistance mechanism driven through GSK3 localization regulation by mTORC1 signaling. 2026. (Under revision)
2.Xu, K., Wang, Y., Wang, F., Guo, Y., Ren, Y., Low, V., Cho, S., Liu, Q., Qiu, Y., Li, X., et al. (2025). SIRT6 Ameliorates Cancer Cachexia–Associated Adipose Wasting by Suppressing TNFR2 Signalling in Mice. J Cachexia Sarcopenia Muscle 16, e13734. https://doi.org/10.1002/jcsm.13734.
3. Koundouros, N., Nagiec, M.J., Bullen, N., Noch, E.K., Burgos-Barragan, G., Li, Z., He, L., Cho, S., Parang, B., Leone, D., et al. (2025). Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling. Science 387, eadm9805. https://doi.org/10.1126/science.adm9805.
4. Kim, J.-S., Cho, S., Jeong, M.-Y., Rivera-Piza, A., Kim, Y., Wu, C., Yoon, Y.E., Lee, I., Choi, J.-W., Lee, H.L., et al. (2025). β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor. Phytomedicine, 156599. https://doi.org/10.1016/j.phymed.2025.156599.
5.He, L*., Cho, S*., and Blenis, J. (2025). mTORC1, the maestro of cell metabolism and growth. Genes Dev 39, 109–131. https://doi.org/10.1101/gad.352084.124.
6. Cho, S., Chun, Y., He, L., Ramirez, C.B., Ganesh, K.S., Jeong, K., Song, J., Cheong, J.G., Li, Z., Choi, J., et al. (2023). FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1. Mol Cell 83, 3010-3026.e8. https://doi.org/10.1016/j.molcel.2023.07.017.
7. Xu, K., Guo, Y., Wang, Y., Ren, Y., Low, V., Cho, S., Ping, L., Peng, K., Li, X., Qiu, Y., et al. (2022). Decreased Enterobacteriaceae translocation due to gut microbiota remodeling mediates the alleviation of premature aging by a high‐fat diet. Aging Cell 22, e13760. https://doi.org/10.1111/acel.13760.
8. Li, Z., Low, V., Luga, V., Sun, J., Earlie, E., Parang, B., Shobana Ganesh, K., Cho, S., Endress, J., Schild, T., et al. (2022). Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nat Commun 13, 6239. https://doi.org/10.1038/s41467-022-33862-0.
9. He, L., Endress, J., Cho, S., Li, Z., Zheng, Y., Asara, J.M., and Blenis, J. (2022). Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells. Science Advances 8, eabm8786. https://doi.org/10.1126/sciadv.abm8786.
10. Tang, H.-W., Weng, J.-H., Lee, W.X., Hu, Y., Gu, L., Cho, S., Lee, G., Binari, R., Li, C., Cheng, M.E., et al. (2021). mTORC1-chaperonin CCT signaling regulates m6A RNA methylation to suppress autophagy. Proceedings of the National Academy of Sciences 118, e2021945118. https://doi.org/10.1073/pnas.2021945118.
11. Cho, S.*, Lee, G.*, Pickering, B.F.*, Jang, C., Park, J.H., He, L., Mathur, L., Kim, S.-S., Jung, S., Tang, H.-W., et al. (2021). mTORC1 promotes cell growth via m6A-dependent mRNA degradation. Molecular Cell 81, 2064-2075.e8. https://doi.org/10.1016/j.molcel.2021.03.010.
12. He, L., Gomes, A.P., Wang, X., Yoon, S.O., Lee, G., Nagiec, M., Cho, S., Chavez, A., Islam, T., Yu, Y., et al. (2018). mTORC1 promotes metabolic reprogramming by suppression of GSK3-dependent Foxk1 phosphorylation. Mol Cell 70, 949-960.e4. https://doi.org/10.1016/j.molcel.2018.04.024.
13. Lee, G., Zheng, Y., Cho, S., Jang, C., England, C., Dempsey, J.M., Yu, Y., Liu, X., He, L., Cavaliere, P.M., et al. (2017). Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling. Cell 171, 1545-1558.e18. https://doi.org/10.1016/j.cell.2017.10.037.
14. Park, J.-G., Xu, X., Cho, S., Hur, K.Y., Lee, M.-S., Kersten, S., and Lee, A.-H. (2016). CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis. Sci Rep 6, 27938. https://doi.org/10.1038/srep27938.
15. So, J.-S., Cho, S., Min, S.-H., Kimball, S.R., and Lee, A.-H. (2015). IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis. Mol Cell Biol 35, 2761–2770. https://doi.org/10.1128/MCB.00215-15.
16. Cho, S.-Y., Cho, S., Park, E., Kim, B., Sohn, E.J., Oh, B., Lee, E.-O., Lee, H.-J., and Kim, S.-H. (2014). Coumestrol suppresses hypoxia inducible factor 1α by inhibiting ROS mediated sphingosine kinase 1 in hypoxic PC-3 prostate cancer cells. Bioorganic & Medicinal Chemistry Letters 24, 2560–2564. https://doi.org/10.1016/j.bmcl.2014.03.084.
17. Cho, S.-Y*., Lee, H.-J*., Lee, H.-J., Jung, D.-B., Kim, H., Sohn, E.J., Kim, B., Jung, J.H., Kwon, B.-M., and Kim, S.-H. (2013). Activation of AMP-Activated Protein Kinase α and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells. Evid Based Complement Alternat Med 2013, 974313. https://doi.org/10.1155/2013/974313.
18. Cho, S.-Y*., Lee, H.-J*., Cho, S.-M., Kim, B., Jung, Y.K., and Kim, S.-H. (2013). Particled Mica, STB-HO has chemopreventive potential via G1 arrest, and inhibition of proliferation and vascular endothelial growth factor receptor 2 in HCT colorectal cancer cells. BMC Complement Altern Med 13, 189. https://doi.org/10.1186/1472-6882-13-189.
19. Henkin, A.H., Ortegon, A.M., Cho, S., Shen, W.-J., Falcon, A., Kraemer, F.B., Lee, S.-J., and Stahl, A. (2012). Evidence for protein-mediated fatty acid efflux by adipocytes. Acta Physiol (Oxf) 204, 562–570. https://doi.org/10.1111/j.1748-1716.2011.02367.x.
20. Cho, S.-Y*., Lee, H.-J*., Jeong, S.-J., Lee, H.-J., Kim, H.-S., Chen, C.Y., Lee, E.-O., and Kim, S.-H. (2011). Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1α inactivation in hypoxic PC-3 prostate cancer cells. Journal of Pineal Research 51, 87–93. https://doi.org/10.1111/j.1600-079X.2011.00865.x.
21. Cho, S.-Y., Jun, H., Lee, J.H., Jia, Y., Kim, K.H., and Lee, S.-J. (2011). Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms. FEBS Letters 585, 3289–3296. https://doi.org/10.1016/j.febslet.2011.09.012.
22. Jun, H.-J., Chung, M.J., Dawson, K., Rodriguez, R.L., Houng, S.-J., Cho, S.-Y., Jeun, J., Kim, J.-Y., Kim, K.H., Park, K.W., et al. (2010). Nutrigenomic analysis of hypolipidemic effects of Agastache rugosa essential oils in HepG2 cells and C57BL/6 mice. Food Sci Biotechnol 19, 219–227. https://doi.org/10.1007/s10068-010-0030-1.
23. Jeun, J., Kim, S., Cho, S.-Y., Jun, H., Park, H.-J., Seo, J.-G., Chung, M.-J., and Lee, S.-J. (2010). Hypocholesterolemic effects of Lactobacillus plantarum KCTC3928 by increased bile acid excretion in C57BL/6 mice. Nutrition 26, 321–330. https://doi.org/10.1016/j.nut.2009.04.011.
24. Chung, M.J., Cho, S.-Y., Bhuiyan, M.J.H., Kim, K.H., and Lee, S.-J. (2010). Anti-diabetic effects of lemon balm (Melissa officinalis) essential oil on glucose- and lipid-regulating enzymes in type 2 diabetic mice. British Journal of Nutrition 104, 180–188. https://doi.org/10.1017/S0007114510001765.
Page updated
Google Sites
Report abuse